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Welcome to JFADdb

Japanese Familial Alzheimer's Disease (JFAD) database contains information about mutations in genes linked to dominantly inherited Alzheimer's disease (APP, PSEN1, and PSEN2) as well as FTDP-17 (MAPT and GRN) in the Japanese population. The database was created by searching for publications in PubMed and ICHUSHI, a bibliographic database of reports published in Japanese language, analyzing FAD and FTDP-17 patients for mutations in respective genes. The database provides comprehensive information for basic researchers and clinicians to obtain an overview of the reported mutations and pedigrees in the Japanese population and compare their findings and clinical presentations with status of the literature.

Latest News

September 5, 2017:  2 new mutations and 4 new cases were added.
June 11, 2015:  7 new mutations and 20 new cases were added.
February 19, 2015:  JFADdb paper was published.
June 24, 2014:  JFADdb launched.


Kensaku Kasuga, Masataka Kikuchi, Takayoshi Tokutake, Akihiro Nakaya, Toshiyuki Tezuka, Tamao Tsukie, Norikazu Hara, Akinori Miyashita, Ryozo Kuwano and Takeshi Ikeuchi. Systematic review and meta-analysis of Japanese familial Alzheimer’s disease and FTDP-17. Journal of Human Genetics (2015) 60, 281-283; doi:10.1038/jhg.2015.15

Last update: September 5, 2017